| イベント名 |
教育の質向上支援プログラム（EEP）セミナー Conditional Cooperativity in Toxin-Antitoxin Battle in Bacteria |
|---|---|
| イベント種類 | セミナー |
| 講演者(講師) | |
| イベント詳細 | 御手洗 菜美子 (Niels Bohr Institute, University of Copenhagen) Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined ”conditional cooperativity”. Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio works best as a transcription repressor. This allows transcription at low toxin level, strong repression at intermediate toxin level, and then again transcription at high toxin level. Such regulation has two interesting features; firstly, it provides a non-monotonous response to the concentration of one of the proteins, and secondly, it opens for ultrasensitivity mediated by the sequestration of the functioning heteromers. We explore possible functions of conditional regulation in simple feedback motifs, and show that it can provide bistability for wide a range of parameters. We demonstrate that the conditional cooperativity in toxin-antitoxin systems combined with the growth-inhibition activity of free toxin can mediate bistability between a growing state and a dormant state. Conditional cooperativity also secures that the antitoxin dominated state has a substantial amount of toxins present, which helps the transition to the toxin dominated state under stress. These features may be relevant for nderstanding persister formation in E. coli. |
| 対象 | 教職員向け 在学生向け |
| 使用言語 | |
| キーワード | |
| 開催期間 | 2013年11月11日 16:00 〜 17:00 |
| 会場 |
|
| 定員 | なし |
| 申込み方法 | 事前申込み不要 |
| お問い合わせ先 |
|
内容を編集する場合はこのボタンをクリックしてください。