| イベント名 |
教育の質向上支援プログラム(EEP)セミナー Theoretical models of collective cellular stress responses |
|---|---|
| イベント種類 | セミナー |
| 講演者(講師) | |
| イベント詳細 | Ala Trusina (Niels Bohr Institute, Copenhagen University) The survival of an organism be it a human or a bacterial colony is not a property of a single isolated cell but relies on a coordinated response of an entire population. To coordinate population response across space -- cells communicate (e.g. quorum sensing in bacteria, cytokine signalling in higher eukaryotes). To coordinate population response across generations cells age. In eukaryotes the aging is manifested through asymmetric distribution of damaged proteins (older cells get most of the damaged proteins), in higher eukaryotes through telomere shortening. We have recently shown that the theoretical model of the inflammatory response exhibits the properties of an excitable medium and has the ability to propagate waves of high cytokine concentration. These waves represent an optimal way of sending an inflammatory signal through the tissue as they create a chemotactic signal able to recruit neutrophils to the site of infection. The simple model displays three qualitatively different states; low stimuli leads to no or very little response. Intermediate stimuli leads to reoccurring waves of high cytokine concentration. Finally, high stimuli leads to a sustained high cytokine concentration, a scenario which is toxic for the tissue cells and corresponds to chronic inflammation. Due to the few variables of the simple model, we are able to perform a phase-space analysis leading to a detailed understanding of the functional form of the model and its limitations. The spatial effects of the model contribute to the robustness of the cytokine wave formation and propagation. If time permits, I will also talk about the model of telomere shortening, which gives a hint on why we age the way we do and how this process allows to reduce mutations in a population of cells. |
| 対象 | 教職員向け |
| 使用言語 | |
| キーワード | |
| 開催期間 | 2013年1月29日 16:30 〜 18:00 |
| 会場 |
|
| 定員 | なし |
| 申込み方法 | 事前申込み不要 |
| お問い合わせ先 |
|
内容を編集する場合はこのボタンをクリックしてください。